:root{--navy:#082d4c;--blue:#1264bf;--teal:#00a2af;--aqua:#e7f6f7;--text:#20344c;--muted:#567088;--line:#dbe7ef;--bg:#f6f9fc}*{box-sizing:border-box}body{margin:0;font:16px/1.65 Inter,system-ui,-apple-system,Segoe UI,Arial,sans-serif;color:var(--text);background:white}a{color:#095dba}a:hover{text-decoration:underline}.skip{position:absolute;left:-9999px}.skip:focus{left:1rem;top:1rem;background:white;padding:1rem;z-index:20}.wrap{max-width:1120px;margin:auto;padding:0 24px}header{position:sticky;top:0;z-index:10;background:#fff;border-bottom:1px solid var(--line);box-shadow:0 3px 20px #1137500b}.head{display:flex;align-items:center;gap:28px;min-height:82px}.logo{text-decoration:none;display:flex;align-items:center;gap:10px;color:var(--navy);min-width:178px}.mark{height:40px;width:40px;border:2px solid var(--navy);border-radius:50%;display:grid;place-items:center;font-weight:800;font-size:16px;letter-spacing:-1px}.brand{font-size:22px;font-weight:800;letter-spacing:-1px}.brand span{color:var(--teal)}.sub{display:block;font-size:9px;letter-spacing:3px;color:var(--muted);margin-top:-7px}.nav{display:flex;gap:15px;align-items:center;flex-wrap:wrap;margin-left:auto}.nav a{text-decoration:none;color:#24445d;font-size:13px;font-weight:650}.nav a.active,.nav a:hover{color:var(--blue)}.btn{display:inline-block;background:#1269d5;color:white!important;border-radius:9px;padding:11px 20px;font-weight:700;text-decoration:none;white-space:nowrap}.btn:hover{text-decoration:none;background:#064c9d}.btn.alt{background:var(--teal)}.btn.ghost{background:white;color:var(--blue)!important;border:1px solid #b6d4ee}.hero{background:linear-gradient(118deg,#062947 0%,#0b4771 65%,#0b6979 100%);color:white;padding:100px 0 90px}.hero h1{font-size:clamp(36px,5vw,60px);line-height:1.12;max-width:800px;margin:0 0 22px;letter-spacing:-1.8px}.hero p{font-size:19px;max-width:710px;color:#dceef7;margin-bottom:29px}.eyebrow{text-transform:uppercase;color:var(--teal);font-size:12px;letter-spacing:2px;font-weight:800}.hero .eyebrow{color:#80ebdf}.actions{display:flex;flex-wrap:wrap;gap:12px}.section{padding:76px 0}.section.soft{background:var(--bg)}h2{font-size:clamp(27px,3vw,38px);line-height:1.24;color:var(--navy);margin:4px 0 18px;letter-spacing:-.6px}h3{font-size:20px;color:var(--navy);margin:4px 0 8px;line-height:1.35}p{margin:0 0 17px}.lead{font-size:19px;color:#4c677c;max-width:770px}.grid{display:grid;grid-template-columns:repeat(3,1fr);gap:20px}.grid.two{grid-template-columns:repeat(2,1fr)}.card{background:white;border:1px solid var(--line);padding:28px;border-radius:15px;box-shadow:0 8px 30px #17384e0b}.card p:last-child{margin-bottom:0}.num{font-size:12px;font-weight:800;color:var(--teal);letter-spacing:1.5px}.notice{border-left:4px solid var(--teal);background:#edf8f9;padding:18px 22px;border-radius:0 12px 12px 0;margin:22px 0}.pagehero{background:linear-gradient(110deg,#082d4c,#0e5278);color:white;padding:69px 0}.pagehero h1{font-size:clamp(32px,4vw,48px);line-height:1.2;margin:6px 0 13px}.pagehero p{color:#dbebf5;max-width:770px;font-size:18px}.body{max-width:850px}.body h2{font-size:27px;margin:38px 0 12px}.body ul{padding-left:22px}.badge{display:inline-block;background:#dcf5f6;color:#116a77;border-radius:99px;font-size:12px;font-weight:800;padding:5px 10px;margin-bottom:10px}.cta{background:#e7f6f7;border:1px solid #b7e1e5;border-radius:16px;padding:35px;margin-top:30px}footer{background:#082940;color:#e7f2f8;padding:52px 0 30px}footer a{color:#b9eaf5}footer .footnav{display:flex;gap:22px;flex-wrap:wrap;margin:12px 0 23px}.fine{font-size:12px;color:#688198}.disclaimer{font-size:13px;color:#53677b;border-top:1px solid var(--line);padding-top:16px;margin-top:28px}.journalcard a{text-decoration:none}.journalcard h3{margin-bottom:12px}.topic{font-size:12px;color:#078b9c;text-transform:uppercase;font-weight:800;letter-spacing:1px}.faq details{border-bottom:1px solid var(--line);padding:16px 0}.faq summary{font-weight:750;color:var(--navy);cursor:pointer}.faq details p{margin-top:13px}.mobile-menu{display:none} @media(max-width:970px){.head{flex-wrap:wrap;padding-top:12px;padding-bottom:14px}.nav{width:100%;justify-content:center;margin:0}.nav a{font-size:12px}.grid{grid-template-columns:repeat(2,1fr)}}@media(max-width:650px){.head{gap:10px;min-height:66px}.logo{margin:auto}.nav{gap:10px}.nav a{font-size:11px}.nav .btn{padding:7px 10px}.hero{padding:65px 0}.section{padding:53px 0}.grid,.grid.two{grid-template-columns:1fr}.card{padding:23px}.cta{padding:24px}}

/* MoleculeDx artwork from the original brand slide; responsive site-wide use */
.logo-symbol{display:block;width:48px;height:50px;object-fit:contain;flex-shrink:0}
.logo-wordmark{display:flex;flex-direction:column;justify-content:center}
.logo .brand{line-height:1.18;white-space:nowrap}
.logo .sub{font-size:9px;line-height:1.4;letter-spacing:2.2px;margin-top:0;white-space:nowrap}
.footer-brand{display:flex;gap:12px;align-items:center;margin-bottom:12px}
.footer-symbol{display:block;width:44px;height:46px;object-fit:contain;background:transparent;border-radius:0;padding:0;filter:brightness(0) invert(1)}
.footer-brand .brand{font-size:24px;color:white;line-height:1.1}
.footer-sub{font-size:9px;letter-spacing:2.4px;line-height:1.5;color:#b9eaf5}
@media(max-width:650px){.logo-symbol{width:42px;height:44px}.logo .brand{font-size:20px}.logo .sub{font-size:8px;letter-spacing:1.6px}}

/* Reconstruction v3: article readability, contact actions, and branded visual motifs */
.article-banner h1{max-width:950px}.article-body{font-size:17px;line-height:1.78;color:#273f55}.article-body>p:first-child{font-size:20px;color:#44617a}.article-body h2{margin-top:42px}.article-body ol,.article-body ul{padding-left:1.7rem}.article-body li{margin-bottom:10px}.article-body table{border-collapse:collapse;width:100%;font-size:14px;margin:24px 0;display:block;overflow-x:auto}.article-body th,.article-body td{border:1px solid #dbe7ef;padding:12px;text-align:left;min-width:135px}.article-body th{background:#e8f5f7}.article-body strong{color:#0c3658}.article-body a{overflow-wrap:anywhere}.article-back{padding-top:20px;font-weight:700}.quiet{color:#607487;font-size:14px}.contact-card h2{font-size:27px}.contact-card .btn{white-space:normal}.contact-next{padding:32px 0}.journal-art{height:150px;border-radius:11px;margin:-8px -8px 20px;background:linear-gradient(120deg,#073552,#0f7791);display:flex;align-items:center;justify-content:flex-end;overflow:hidden;position:relative}.journal-art:before{content:'';position:absolute;width:190px;height:190px;border:23px solid #ffffff20;border-radius:50%;left:-55px;top:-30px}.journal-art:after{content:'';position:absolute;width:145px;height:145px;border:13px solid #ffffff22;border-radius:50%;right:-28px;bottom:-85px}.journal-art span{font-weight:900;letter-spacing:4px;color:#d7faf8;font-size:32px;transform:rotate(-7deg);padding:22px;z-index:1}.journal-art.art-2{background:linear-gradient(110deg,#082d4c,#23869a)}.journal-art.art-3{background:linear-gradient(120deg,#154d72,#76b3bb)}.journal-art.art-4{background:linear-gradient(125deg,#053c50,#0ca8a6)}.journal-art.art-5{background:linear-gradient(110deg,#14364c,#327c9f)}.journalcard{display:flex;flex-direction:column}.journalcard>a:last-child{margin-top:auto;padding-top:15px;font-weight:700}.journalcard p{flex:1}.article-body blockquote{border-left:4px solid var(--teal);margin:25px 0;padding:10px 20px;background:var(--aqua)}
@media(max-width:650px){.article-body{font-size:16px}.journal-art{height:135px}.contact-card .btn{width:100%;text-align:center}}


/* V4: published scientific and clinical evidence for physician readers */
.provider-evidence{margin:28px 0 44px;padding:22px 0;border-top:2px solid #b6dce6;border-bottom:2px solid #b6dce6}
.provider-evidence h3{margin-top:29px;font-size:21px}
.study-stats{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:12px;margin:20px 0 16px}
.study-stats>div{background:#edf7f9;border:1px solid #c7e6ed;border-radius:12px;padding:18px;min-width:0}
.study-stats strong{display:block;font-size:25px;color:#07566b}
.study-stats span{display:block;font-size:13px;color:#425c72;line-height:1.4}
.table-scroll{overflow-x:auto;max-width:100%;border:1px solid #dae8ee;border-radius:12px;margin:20px 0}
.clinical-table{border-collapse:collapse;width:100%;min-width:660px;font-size:14px;line-height:1.5}
.clinical-table caption{text-align:left;padding:14px 16px;color:#173e5a;background:#edf6f9;font-weight:750}
.clinical-table th,.clinical-table td{border-bottom:1px solid #e3edf3;padding:13px 12px;text-align:left;vertical-align:top}
.clinical-table thead th{background:#e7f3f6;color:#082d4c}
.clinical-table tbody tr:nth-child(even){background:#f7fbfc}
.clinical-table td:not(:nth-child(2)){font-variant-numeric:tabular-nums;white-space:nowrap}
.study-source{font-size:14px;color:#4b6478}
@media(max-width:650px){.study-stats{grid-template-columns:1fr}.provider-evidence{padding-top:14px}}


/* V5: HCC epidemiology, population outcomes, and third-party literature */
.epi-section .lead{max-width:970px}
.epi-grid{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:15px;margin:31px 0 22px}
.epi-stat{background:white;border:1px solid #d5e7f0;border-top:4px solid var(--teal);border-radius:13px;padding:24px 20px;box-shadow:0 8px 24px #153f6010;min-width:0}
.epi-stat:nth-child(2){border-top-color:#247fba}.epi-stat:nth-child(3){border-top-color:#1269d5}.epi-stat:nth-child(4){border-top-color:#1b87ab}
.epi-stat-number{font-size:clamp(24px,2.45vw,36px);line-height:1.05;color:var(--navy);font-weight:850;letter-spacing:-1.3px;margin:0 0 19px;white-space:nowrap;font-variant-numeric:tabular-nums}
.epi-stat h3{font-size:17px;line-height:1.3;margin:0 0 9px}
.epi-stat>p:not(.epi-stat-number){font-size:14px;line-height:1.55;color:#4b6376}
.epi-stat .epi-stat-source{margin:13px 0 0;font-size:12px;color:#516f83}
.epi-stat-source a{color:#0c5a98;font-weight:650;text-underline-offset:3px}
.epi-footnote{color:#536c7f;font-size:13px;max-width:1000px;line-height:1.65}
.epi-evidence-layout{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:22px;margin:27px 0 20px}
.epi-panel{padding:30px;border:1px solid #dae8ee;border-radius:16px;background:#fff;box-shadow:0 8px 24px #14354d0b}
.epi-panel h3{font-size:22px;margin-bottom:24px}
.survival-row{display:grid;grid-template-columns:155px minmax(0,1fr);align-items:center;gap:18px;margin-bottom:22px}
.survival-row strong{display:block;color:#093c61;font-size:33px;line-height:1;font-variant-numeric:tabular-nums}
.survival-row span{font-size:12px;color:#4b687c}
.survival-track{height:17px;background:#ebf2f6;border-radius:30px;overflow:hidden}
.survival-fill{height:100%;border-radius:30px}.survival-fill.localized{background:#00a3ac}.survival-fill.distant{background:#e28067;min-width:6px}
.epi-panel-detail{background:#edf7f9;border-radius:10px;padding:15px;font-size:15px;color:#234f64}
.epi-mini-stat{display:flex;align-items:center;gap:16px;margin:18px 0;padding:15px 0;border-bottom:1px solid #deeaee}
.epi-mini-stat strong{font-size:35px;color:var(--navy);white-space:nowrap;font-variant-numeric:tabular-nums;line-height:1}
.epi-mini-stat span{font-size:14px;line-height:1.5;color:#40596f}
.epi-risk-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:19px;margin:28px 0}
.epi-risk-item{border-left:4px solid #0d9aa7;background:#fff;border-radius:0 12px 12px 0;padding:22px}
.epi-risk-item h3{font-size:18px}
.epi-guideline{display:flex;align-items:center;gap:30px;padding:27px;border:1px solid #b9dde5;border-radius:16px;background:#e5f4f6}
.epi-guideline-big{font-size:29px;font-weight:850;color:#085b6c;min-width:165px;line-height:1.15}
.epi-guideline h3{font-size:20px}
.epi-guideline p{font-size:15px;margin-bottom:10px}
.epi-references .lead{max-width:960px}
.epi-reference-list{font-size:14px;line-height:1.6;padding-left:25px;max-width:1010px}
.epi-reference-list li{margin:0 0 14px;padding-left:4px}
.epi-reference-list a{color:#165d90;text-underline-offset:3px;overflow-wrap:anywhere}
@media(max-width:970px){.epi-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.epi-evidence-layout{grid-template-columns:1fr}}
@media(max-width:650px){.epi-grid,.epi-risk-grid{grid-template-columns:1fr}.epi-stat-number{font-size:33px}.epi-panel{padding:23px}.survival-row{grid-template-columns:115px minmax(0,1fr);gap:12px}.survival-row strong{font-size:28px}.epi-guideline{display:block}.epi-guideline-big{margin-bottom:13px}.epi-section .lead{font-size:17px}}

/* V7: clinician-facing utility — 2024 research-informed scenarios */
.clinical-utility{margin:44px 0 54px;padding:36px;background:linear-gradient(150deg,#f1f9fb,#f7fbff);border:1px solid #cce8ed;border-radius:20px}
.clinical-utility-heading h2{margin:9px 0 13px;font-size:clamp(27px,3vw,36px)}
.clinical-utility-lead{font-size:18px;line-height:1.65;color:#37576c;max-width:900px}
.utility-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:18px;margin:24px 0}
.utility-card{background:white;border:1px solid #d3e5ec;border-radius:15px;padding:25px;box-shadow:0 8px 28px #1747600b}
.utility-heading{display:flex;align-items:center;gap:13px;margin-bottom:14px}
.utility-index{background:#e3f6f7;color:#077887;border-radius:9px;padding:5px 11px;font-size:17px;font-weight:800;letter-spacing:1px}
.utility-tag{font-size:12px;letter-spacing:.7px;text-transform:uppercase;color:#367587;font-weight:800}
.utility-card h3{font-size:22px;margin:0 0 13px}
.utility-card p{font-size:15px;line-height:1.65;color:#29445b}
.utility-card strong{color:#0b3555}
.utility-card p:last-child{margin-bottom:0}
.utility-context{border-bottom:1px solid #e3edf1;padding-bottom:15px;margin-bottom:15px}
.utility-evidence{margin-top:17px;padding:14px;background:#eaf8f9;border-left:3px solid #05a0ab;border-radius:0 8px 8px 0;font-size:14px;color:#284d60;line-height:1.6}
.utility-study-note{margin-top:20px;font-size:13px;line-height:1.7;color:#4d6a7a}
.utility-study-note a{font-weight:700}
@media(max-width:720px){.clinical-utility{padding:22px 17px}.utility-grid{grid-template-columns:1fr}.utility-card{padding:20px}.utility-card h3{font-size:20px}}

/* V8 clinical-utility emphasis and clinician interpretation guide */
.clinical-utility{background:linear-gradient(145deg,#eaf8fa 0%,#f8fcff 100%);border-color:#b6e3e8}
.clinical-utility-lead{color:#294c65}
.utility-card{box-shadow:0 10px 30px #164a6b10}
.utility-card h3{font-size:22px}
.utility-evidence{font-size:15px;font-weight:500}
.response-block{margin:8px 0 24px}
.response-block>p{line-height:1.75}
.response-guide{background:#f5fafc;border:1px solid #cde4eb;border-radius:15px;padding:5px 21px;margin:23px 0}
.response-row{display:grid;grid-template-columns:minmax(175px,215px) 1fr;gap:21px;align-items:start;padding:20px 0;border-bottom:1px solid #d3e3ea}
.response-row:last-child{border-bottom:0}
.response-label{padding:10px 12px;border-radius:8px;font-weight:750;line-height:1.4;font-size:15px;color:#07566c;background:#e1f6f8}
.response-label.watch{color:#64530d;background:#fff5d4}
.response-label.warning{color:#7f3630;background:#fce9e6}
.response-row p{margin:0;font-size:15px;line-height:1.75}
.response-caveat{font-size:13px;color:#547087}
@media(max-width:650px){.response-row{display:block}.response-label{margin:0 0 12px;display:block}.response-guide{padding:5px 15px}}


/* V12: confirmed corporate contact details — contact page and footer */
.contact-details{margin:0 0 42px}
.contact-details-intro{margin-bottom:24px}
.contact-details-intro h2{margin:6px 0 10px}
.contact-details-intro p{font-size:17px;color:#4d677a;max-width:800px}
.contact-detail-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:18px}
.contact-detail-card{border:1px solid #cfe2ea;border-radius:15px;background:linear-gradient(160deg,#fff,#f6fbfc);padding:24px;min-width:0}
.contact-detail-icon{height:41px;width:41px;display:grid;place-items:center;background:#def4f6;color:#075e73;border-radius:12px;font-size:25px;font-weight:750;margin-bottom:14px}
.contact-detail-card h3{font-size:19px;margin-bottom:9px}
.contact-detail-card a{font-size:17px;font-weight:750;color:#0a6197;text-decoration:none;overflow-wrap:anywhere}
.contact-detail-card a:hover{text-decoration:underline}
.contact-detail-card address{font-size:16px;font-style:normal;line-height:1.65;color:#294862}
.contact-detail-card address strong{color:#073856}
.contact-detail-card p{font-size:14px;color:#567187;margin:12px 0 0}
.contact-provider-email{font-weight:750}
.footer-contact{display:flex;flex-wrap:wrap;gap:7px 22px;padding:14px 0;margin:8px 0 10px;border-top:1px solid #326078;border-bottom:1px solid #326078;font-size:13px;line-height:1.7;color:#d2e9f3}
.footer-contact strong{color:white}
.footer-contact-links{display:inline-flex;gap:9px;flex-wrap:wrap}
.footer-contact a{color:#b9eaf5;text-decoration:none}
.footer-contact a:hover{text-decoration:underline}
@media(max-width:850px){.contact-detail-grid{grid-template-columns:1fr}.contact-detail-card{padding:22px}}

/* V13: keyboard accessibility and contextual article navigation */
:focus-visible { outline: 3px solid #087c94; outline-offset: 3px; }
.article-next { margin-top: 2.4rem; padding: 1.3rem 1.5rem; border: 1px solid var(--line); border-radius: 14px; background: #f6f9fc; }
.article-next-links { display:flex; flex-wrap:wrap; gap: 1.2rem; margin-top:0.4rem; }
.article-next-links a { font-weight: 650; }
@media (prefers-reduced-motion: reduce) { *, *::before, *::after { scroll-behavior:auto !important; animation-duration:0.01ms !important; transition-duration:0.01ms !important; } }